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Short-term vs conventional glucocorticoid therapy in acute exacerbations of chronic obstructive pulmonary disease the reduce randomized clinical trial – jama 2013 pmid 23695200 design randomized, placebo-controlled trial n 311, length 180 days treatment treatment with 40 mg of prednisone daily for either 5 or 14 days in a placebo-controlled, double-blind fashion primary outcome time to next exacerbation within 180 days findings in patients presenting to the emergency department with acute exacerbations of copd, 5-day treatment with systemic glucocorticoids was noninferior to 14-day treatment with regard to reexacerbation within 6 months of follow-up but significantly reduced glucocorticoid exposure.

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