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During that same period there was a 80 increase in colchicine prescriptions to treat initial gout attacks.

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other drugs that may increase methotrexate toxicity include barbiturates, proton pump inhibitors pantoprazole, omeprazole, esomeprazole, lansoprazole, rabeprazole , colchicine, dipyridamol, phenytoin, sulfonylureas, frusemide furosemide and thiazide diuretics.

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symptoms of colchicine overdose start 2 to 24 hours after the toxic dose has been ingested and include burning in the mouth and throat, fever, vomiting, diarrhea, and abdominal pain.

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regardless of the absolute primacy of the cytoskeleton or some other molecule in the sensation and relay of pressure-derived signals, microtubule disruption by colchicine appears sufficient to inhibit pressure-mediated functional effects on cell adhesion.

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case reports and epidemiology studies in female subjects on colchicine therapy have not established a clear relationship between colchicine use and female infertility.
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