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An adjustment in the diltiazem lp dose may be warranted.

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patients taking other drugs that are substrates of cyp450 3a4, especially patients with renal and or hepatic impairment, may require dosage adjustment when starting or stopping concomitantly administered diltiazem in order to maintain optimum therapeutic blood levels.

- combined use of the medication with calcium channel blockers based on verapamil and diltiazem, increase the risk of atrioventricular block.

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