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An adjustment in the diltiazem lp dose may be warranted.

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letermovir moderate a clinically relevant increase in the plasma concentration of diltiazem may occur during concurrent administration with letermovir.

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dextromethorphan; quinidine major diltiazem significantly decreases the clearance and increases the half-life of quinidine.

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doxercalciferol moderate cyp450 enzyme inhibitors, like diltiazem, may inhibit the 25-hydroxylation of doxercalciferol, thereby decreasing the formation of the active metabolite and thus, decreasing efficacy.

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oral coadministration of diltiazem and methylprednisolone has been shown to increase the auc of methylprednisolone by about 2.

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patients taking other drugs that are substrates of cyp450 3a4, especially patients with renal and or hepatic impairment, may require dosage adjustment when starting or stopping concomitantly administered diltiazem in order to maintain optimum therapeutic blood levels.
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- combined use of the medication with calcium channel blockers based on verapamil and diltiazem, increase the risk of atrioventricular block.

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